Another mouse model, generated by intrahippocampal injection of oligometric forms of the Aβ peptide, demonstrated that systemic injection of ghrelin rescued performance on two behavioral paradigms (Y-maze and passive avoidance tasks), as well as attenuated AD-associated neuropathological abnormalities, possibly by inhibiting microgliosis and protecting neuronal integrity (Moon et al., 2014). This evidence concerns the gene GHRL and Alzheimer disease.