MAPT and Alzheimer disease: In AD and other tauopathies such as progressive supranuclear palsy (PSP) and frontotemporal dementia associated with parkinsonism linked to chromosome 17, a phenomenon of abnormal Tau hyperphosphorylation or phosphorylation is responsible for a set of alterations, such as axonal transport and mitochondrial and lysosomal dysfunction, among other functions associated with MTs, that can lead to neuronal degeneration (Avila et al., 2004; Iqbal et al., 2009).