Canonical signaling analysis of the cortex revealed a strong bias toward cytokine signaling (Leptin signaling in obesity, JAK family kinases in IL-6-type signaling), neurodegenerative disease related activity (Amyloid processing, CDK5 signaling, CNTF signaling) and energy metabolism (IGF-1 signaling) (Figure 5C: Table 5). Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.