Inspecting the top ten highest scoring KEGG pathways from cortical proteins (Figure 5A: Table 3) a strong population of metabolic (Glutathione metabolism, Insulin signaling pathway, Metabolic pathways), neurotransmission/degenerative (Neurotrophic signaling pathway, Alzheimer's disease) and ultrastructural (Gap junction, Tight junction, Spliceosome) signaling pathways was evident. The gene discussed is INS; the disease is early-onset autosomal dominant Alzheimer disease.