Recent work of our team showed that Cp oxidation, which occurs in neurodegenerative diseases as a consequence of an oxidative environment, promotes the gain of integrin-binding function and triggers intracellular signaling, that through ERK1/2, Akt and mitogen-activated protein kinase (MAPK) signaling pathways involvement, may regulate gene activation, cell cycle and proliferation [6,10]. The gene discussed is MAPK3; the disease is neurodegenerative disease.