As shown in Table 2, the expression level of PN was associated with pathologic subtype (P = 0.000, odds ratio (OR) = 8.143), tumor size (P = 0.016, OR = 9.370) and Enneking stage (P = 0.047, OR = 1.324), but there was no significant correlation with age, gender, location, alkaline phosphatase level, serum albumin level and ESR. The gene discussed is ALB; the disease is neoplasm.