The characteristics of the groups are listed in Table 2; there were significant differences in tumor diameter, DMVD (edge-center), grade of DMVD, number of metastatic nodes, clinical stage, ER, PgR, Her2, Ki67, clinicopathological subtypes, and endocrine therapy among the groups (P < 0.05) [Table 2]. The gene discussed is ESR1; the disease is neoplasm.