However, this translational research is of clinical relevance because it reveals new concept of interaction of sildenafil with the RAS and opens the perspective of using sildenafil to stimulate the production of Ang 1–7 as a new therapeutic approach for the treatment of renovascular hypertension an endothelial dysfunction, as well as for resistant hypertension. The gene discussed is ANGPT1; the disease is Hypertension resistant to conventional therapy.