Conversely, Gemignani et al. showed that the shorter allele (A1) should be related to the higher expression of TP53[14], however, their analyses were based on immortalized normal lymphocyte cells, known to present domains of monoallelic expression, which are possibly artifactual[26], and which may insufficiently reflect the conditions within tumor cells irrespective of the cell origin[14]. This evidence concerns the gene TP53 and neoplasm.