It is worth mentioning that a recent study by Raeven and colleagues has used a similar approach to our study in the sense that it compared endothelial dysfunction marker levels (PAI-1, thrombomodulin) in dying/surviving subgroups of animals subjected to CLP (in this study, the context was to determine if a pre-existing trauma amplifies subsequent CLP outcomes). Here, SERPINE1 is linked to endothelial dysfunction.