TYMS and cancer: A number of drug-related genetic factors include 5-FU metabolism-associated genes (for example, thymidylate synthase (TYMS), deoxythymidylate kinase (DTYMK)) [14], taxol-related genes (Class III β-tubulin (TUBB3)) [15], and platinum-related genes (for example, excision repair cross-complementation group (ERCC1) and breast cancer 1, early onset (BRCA1)) [16].