INS and Hypoinsulinemia: By contrast, insulin treatment significantly attenuated diabetes-induced hyperglycemia (350 ± 51 vs. 508 ± 43 mg/dl, P < 0.05), and hypoinsulinemia (1.66 ± 0.41 vs. 0.61 ± 0.10 μg/l, P < 0.01; Table 1).