INS and Hypoinsulinemia: By contrast, insulin treatment (4 IU/rat/day) for 1 week significantly attenuated diabetes-induced body weight loss (329 ± 14 vs. 292 ± 11 g, P < 0.05), hyperglycemia (153 ± 10 vs. 460 ± 15 mg/dl, P < 0.001), and hypoinsulinemia (2.04 ± 0.55 vs. 0.56 ± 0.07 μg/l, P < 0.05) (Table 1).