For women with PCOS, BMI (OR: 1.420, 95% CI 1.328-1.518) and FAI (OR: 1.132, 95% CI 1.037-1.236) were risk factors for MetS, while SHBG (OR: 0.995, 95% CI 0.990-1.000) was protective factor. The gene discussed is SHBG; the disease is metabolic syndrome.