Xpert test detected slightly more TB cases than LJ, only among participants with CD4 cell count >200 cells/mm3 (Table 4).The sensitivity of Xpert decreased near-significantly from 91.7% (95% CI 73.0–98.9%) among participants with CD4 cell count >200 cells/mm3 to 73.2% (95% CI 63.2–81.7%) among participants with CD4 cell count ≤200 cells/mm3 (p = 0.062). This evidence concerns the gene CD4 and tuberculosis.