Although the effect of derived rs9368197 allele on glucose-induced insulin response is similar to that reported for the derived rs7754840 allele, the finding that the derived rs7754840 allele (i.e., C) is associated with an elevated GIP response is unique because the same allele has been found to be associated with type 2 diabetes and reduced insulin secretion in earlier studies [43], [44], [45], [46]. This evidence concerns the gene INS and type 2 diabetes mellitus.