With the exception of GAD2 variant rs2236418, none of the candidate variants had been implicated in earlier GWA studies although CDKAL1, CYB5R4, and PPARG loci have been associated with diabetes- and/or obesity-related traits [7], [8], [9], [10], [11], [12]. This evidence concerns the gene GAD2 and obesity due to melanocortin 4 receptor deficiency.