T2D mice exhibited reduced phosphorylation of Akt (1.00±0.06 vs. 1.97±0.09 of CH mice, p<0.01, n = 5–8) and its downstream effector, GSK3β (1.00±0.08 vs. 1.60±0.21 of CH mice, p<0.05, n = 5–8) throughout the course of experiment. The gene discussed is GSK3B; the disease is type 2 diabetes mellitus.