T2D mice showed decreased phosphorylation of FoxO1 (1.00±0.07 vs.1.43±0.10 of CH mice, p<0.05, n = 5–8) and increased total content of FoxO1 (1.00±0.13 vs. 0.75±0.12 of CH mice, n = 5–8) compared to non-diabetic CH mice. Here, FOXO1 is linked to type 2 diabetes mellitus.