Along with this, the mRNA expression of G6Pase, which is a rate-limiting regulator for gluconeogenesis, was also found to be up-regulated in the T2D mice (1.00±0.17 vs. 0.72±0.15 of CH mice, during OA treatment; 1.00±0.27 vs. 0.59±0.21 of CH mice, post-OA treatment, all n = 5–8). This evidence concerns the gene G6PC1 and type 2 diabetes mellitus.