In the T2D patients, compared with the control subjects, the levels of TBARS, a measure of lipoperoxidation, were increased by 67% (p<0.001), while the levels of ascorbic acid, reduced glutathione and SOD activity were decreased by 5%, 13% and 48%, respectively (p<0.001). The gene discussed is SOD1; the disease is type 2 diabetes mellitus.