ANXA5 and neoplasm: Indeed, Belluoccio et al. reported significant alteration in the transcriptome of compound AnxA5−/−;AnxA6−/−, wherein 56% of differentially-regulated genes (defined by 3-fold difference compared to control) were related to cell survival, involving cell motility, apoptosis, cell cycle, cell proliferation and differentiation and tumor suppressor/survival [8].