As a monotherapy, the EGFR-TKI erlotinib, was shown to improve progression free survival (PFS) (2.2 vs. 1.8 months, p < 0.001) and overall survival (OS) over best supportive care (6.7 vs. 4.7, p < 0.001) in unselected NSCLC patients with advanced disease who had failed one or two prior lines of chemotherapy (BR 21) (10). This evidence concerns the gene EGFR and non-small cell lung carcinoma.