Given encouraging preclinical data in ALK-driven tumors resistant to crizotinib (68), ganetespib is being investigated in clinical trials in NSCLC patients with ALK-driven tumors, as a monotherapy in heavily treated (crizotinib naïve) patients (www.clinicaltrials.gov: NCT01562015) and in combination with crizotinib in patients with prior exposure to crizotinib (www.clinicaltrials.gov: NCT01579994). The gene discussed is ALK; the disease is non-small cell lung carcinoma.