AKT1 and cancer: CDDP-R cells show an increase in the phosphorylation of AKT, mTOR, and the S6 ribosomal subunit (Ser 473, 2448, and 240/244, respectively), without a change in total protein expression, indicating that these cells' metabolism mimics the biochemical alterations characteristic of many cancers, and pointing towards a potential therapeutic role for the selective dual pan-class I PI3K and mTOR kinase inhibitor BEZ-235 [19].