PRDX2 and Alzheimer disease: Proteomics studies on Tg mAPP/ABAD mice showed that in brain the ABAD-Aβ interaction also affects the expression of proteins such as Ep-1 (endophilin-1), a cytoplasmic SH3 domain-containing protein, located in presynaptic nerve termini [79] and Prdx-2 (peroxiredoxin-2), an antioxidant protein [80], both of which were also found to be overexpressed in human AD brains [79, 80].