Specifically, IFN-ε’s ability to enhance CD8+ T cell homing to the gut [gut is the primary site of HIV virus replication and CD4+ T-cell depletion (119)] and also its ability to control infections at the lung mucosae suggest that administration of pegylated forms of IFN-ε or vaccines encoding IFN-ε could be effective for controlling mucosal pathogens such as HIV-1. Here, IFNE is linked to infection.