CDKN2A and cancer: Furthermore, we showed that the induced RCCs have massive chromosomal alterations similar to those of human cancers, of which the amplification of c-Met (receptor for hepatocyte growth factor) and deletion of Cdkn2a/2b (p16Ink4a/p15Ink4b tumor suppressor genes) are most common (Tanaka et al., 1999; Akatsuka et al., 2012).