SOX2 and cancer: Recently, it was shown that doxycycline-controlled reprogrammable transgenic mice overexpressing the four Yamanaka factors (Oct3/4, Sox2, Klf4, and c-Myc) for induced pluripotent stem cell generation develop several cancers similar to childhood blastoma-type cancer that do not revert to normal and continue dysplastic growth, even after switching off those genes.