It is noteworthy that IL-6 (Payette et al., 2003), TNF-α (Pedersen et al., 2003), CRP (Cesari et al., 2005), and SAA (Zhang et al., 2009) have all been implicated in the pathogenesis of muscle atrophy in the context of sarcopenia or other muscle-wasting disorders. This evidence concerns the gene TNF and muscle atrophy.