Mutations in the LAMA2 gene, encoding the α2 chain of laminin-2, cause α 2-laminin deficiency and a severe form of congenital muscular dystrophy (CMD1A) linked to chromosome 6q (Helbling-Leclerc et al., 1995). The gene discussed is LAMA2; the disease is congenital muscular dystrophy due to LMNA mutation.