MYOT and limb-girdle muscular dystrophy: For example, knockout mice for α-sarcoglycan gene accurately resemble the LGMD-2D phenotype (Duclos et al., 1998), a deletion on dysferlin gene produces a LGMD-2B phenotype in SJL-Dysf mice (Bittner et al., 1999), while mice carrying mutations on myotilin gene develop the autosomal dominant LGMD-1A (Liu et al., 2014).