In addition to promoting survival and inducing synaptic plasticity, BDNF also regulates adult neurogenesis (Scharfman et al., 2005; Henry et al., 2007; Bath et al., 2011), which appears to be altered in HD mouse models and human postmortem brains (Curtis et al., 2003; Gil et al., 2005; Phillips et al., 2005). Here, BDNF is linked to Huntington disease.