CX3CR1 and coronary artery disorder: In 2009, Apostolakis et al. [43] performed a meta-analysis to evaluate the association between the CX3CR1 T280M and V249I polymorphisms and CAD and demonstrated that the CX3CR1 280M allele was associated with a reduced risk of CAD in the heterozygous state and 249I-280M haplotype had a atheroprotective effect on CAD.