TP53 and squamous cell carcinoma: In a recent meta-analysis, including 1353 cervical tumors the frequency of non-synonymous mutations in the DNA-binding domain of the TP53 gene was found significantly higher in adenocarcinoma (32 of 241; 13.3%) compared to squamous cell carcinoma (39 of 657; 5.9%; P = 0.0003, χ2 test), [10].