PIK3CA and cervical carcinoma: These results are in agreement with PIK3CA mutation frequencies reported in COSMIC (Catalogue of Somatic Mutations in Cancer) database (11% and 14% in adenocarcinoma and squamous cell carcinoma, respectively) and with those recently obtained by whole exome sequencing analysis of cervical cancer genomes (PIK3CA mutation frequencies of 12.5% and 12.6% in adenocarcinoma and squamous cell carcinoma, respectively) [18,43].