Moreover, Cui et al. [44] analyzing exon 1, 9 and 20 of PIK3CA gene in cervical carcinomas and CIN3 lesions identified somatic mutations in 8.15% of cervical carcinomas but no mutations in CIN3 cases suggesting that genetic alterations of this proto-oncogene are late events during carcinogenesis. The gene discussed is PIK3CA; the disease is cervical carcinoma.