Activating-type FcR, such as FcγRI, FcγRIIa and FcγRIIIa which are characterized by the presence of a cytoplasmic immune-receptor tyrosine-based activation motif (ITAM) sequence, promote disease development and the inhibitory-type, FcgammaRIIB which is characterized by the presence of an immune-receptor tyrosine-based inhibitory motif (ITIM), can suppress antibody-mediated autoimmunity [141]. This evidence concerns the gene FCGR2B and Autoimmunity.