In contrast, the five genes that demonstrated the most significant downregulation were tyrosine aminotransferase (TAT), Jun dimerization protein 2 (JDP2), hydroxysteroid (17-beta) dehydrogenase 13 (HSD17B13), cytochrome P450 family 2 subfamily B polypeptide 6 (CYP2B6), and phosphoenolpyruvate carboxykinase 1 (PCK1), which showed greater than 30-fold lower expression in HCC tumors than adjacent non-tumor tissues. The gene discussed is HSD17B13; the disease is hepatocellular carcinoma.