Several of the aggregation-prone yeast proteins identified in this current study have human or mouse orthologues that are implicated in protein folding disorders and/or co-aggregate with specific folding disease-associated proteins in AD (Liao et al., 2004; Wang et al., 2005), familial ALS (Basso et al., 2009) or PD (Xia et al., 2008) (supplementary material Table S4). This evidence concerns the gene PROS1 and Alzheimer disease.