The phenotype of the PANTG mouse as compared to the PANKO-C57 mouse is strikingly concordant in terms of the following observations: (1) fasting glucose, C-peptide and insulin levels are elevated (decreased in PANKO-C57), (2) hepatic insulin sensitivity is decreased, (3) hepatic phosphorylated AMPK is decreased during insulin stimulatory conditions, and (4) glucose intolerance is observed during GTTs (Robert-Cooperman et al., 2014). This evidence concerns the gene INS and Glucose intolerance.