INS and type 2 diabetes mellitus: This difference might be attributed to the effect that the host genome can have on numerous metabolic factors, such as insulin secretion or peripheral and hepatic sensitivity (Doetschman, 2009; Kahle et al., 2013), particularly in the C57BL/6J mouse model, which serves as a common in-bred strain of diet-induced T2D (Freeman et al., 2006; Toye et al., 2005).