To evaluate the mechanism of elimination of extracellular oligomeric tau present in the brains of tauopathy patients, we analyzed phagocytic activity of BV2 mouse microglia cell line, a widely used valid model of microglial cells [42,43], and monocytic/macrophage cell line J774A.1 (ATCCTM TIB67TM) as a surrogate for primary macrophages [44]. The gene discussed is MAPT; the disease is tauopathy.