In DKO* mice, LCs within the epidermis as well as in lymph nodes exhibited higher levels of CD205, PD-L1, and CD86, which have been associated with DC-mediated generation of regulatory T cells (Bonifaz et al, 2002), peripheral T-cell tolerance (Salomon et al, 2001), and protection from spontaneous autoimmunity (Probst et al, 2005). This evidence concerns the gene CD274 and Autoimmunity.