Whereas little is known about the roles of the different DC subsets in psoriasis, recent reports indicate that DCs are an important source of IL-23, a cytokine that seems to have, along with TNF-α and IL-17, a central role in psoriasis pathology (Brunner et al, 2013; Di Cesare et al, 2009; Gunther et al, 2013; Wohn et al, 2013). This evidence concerns the gene TNF and psoriasis.