The volume of HER3-positive tumor xenografts was significantly smaller in mice treated with 2 or 10 mg/kg pertuzumab than in animals treated with vehicle alone (controls) (p=0.0052 for HPAC; p=0.0269 for CFPAC-1; p<0.001 for BxPC-3 cells) (Figure 2C). The gene discussed is ERBB3; the disease is neoplasm.