Conversely, only a slight inhibition of tumor growth (possibly due to activation of immune cells through ADCC or inhibition of HER2/HER1 heterodimers by pertuzumab) and no significant increase in survival were observed in mice xenografted with shHER3 BxPC-3 cancer cells and treated with pertuzumab in comparison to untreated controls (p=0.002; p=0.086) (Figure 3E). The gene discussed is ERBB2; the disease is cancer.