Treatment with pertuzumab (24 h) led to HER3 protein increase, which could be involved in bypassing the pertuzumab-induced HER2 inhibition, as observed by Garrett et al [24] in breast cancer cells treated with the HER2 inhibitor lapatinib, and by Nagumo et al [25] in ovarian cancer cells and breast cancer xenografts treated with pertuzumab. This evidence concerns the gene ERBB2 and breast carcinoma.