To validate whether SENP3 could induce the EMT in gastric cancer, we established two stable cell lines in which SENP3 was over-expressed in one with low basal SENP3 (SGC7901-SENP3) or knocked-down in one with high basal SENP3 (MGC803-sh-SENP3). The gene discussed is SENP3; the disease is gastric cancer.