IGF2BP3 can also induce cell proliferation and invasiveness via post-transcriptional regulation of IGF2; the resulting IGF2 then activates oncogenic phosphatidylinositcol 3-kinase/mitogen-activated protein kinase (PI3K/MAPK) pathways in glioblastomas [7, 8]. The gene discussed is IGF2; the disease is glioblastoma.