Nude mice were injected with control-RNAi S2-013 cells, and cytoplasmic granules containing IGF2BP3 were evident in the penumbra of each primary pancreatic tumor taken from such a mouse; moreover, ARF6 was enriched near cell membranes in the penumbra of each tumor (Figure 6D). This evidence concerns the gene ARF6 and pancreatic neoplasm.