ARF6 is localized at invadopodia of cultured breast cancer cells and plays pivotal roles in actin-cytoskeletal remodeling at the cell periphery; moreover, suppression of ARF6 effectively blocks the invasive activities of these breast cancer cells—including the formation of invadopodia, localized matrix degradation, and Matrigel transmigration [22, 23]. Here, ARF6 is linked to breast carcinoma.