Besides migratory and invasive processes, angiogenesis appears to be of particular importance in the physiopathology of lymphomas, as disease progression was found to correlate with increased angiogenic activity.[46] In this sense, involvement of PI3K/Akt/mTOR pathway in cell invasion and angiogenesis has been proposed in follicular lymphoma.[47] Here, we provide the first evidence of NVP-BEZ235 ability to interfere with the angiogenic process. The gene discussed is PIK3CA; the disease is lymphoma.