Indeed, the importance of vitamin D in regulating innate and adaptive immunity has been highlighted by studies demonstrating inhibition of interferon α (IFN α)-mediated monocyte differentiation into dendritic cells, increased serum IFN α activity in SLE patients with vitamin D deficiency, decreased proliferation and production of polyclonal immunoglobulin G (IgG) and anti-dsDNA IgG in SLE PBMC treated with vitamin D and the regulation of dividing plasmablasts and long-lived plasma cells [27,28,29,30]. This evidence concerns the gene IFNA1 and systemic lupus erythematosus.