Conditional macrophage ablation in combination with transgenic and gene deletion mouse models have demonstrated that CD11c+ macrophages, Nlrp3-inflammasome components and pro-inflammatory cytokines promote glucose intolerance and IR in both diet-induced obesity (DIO) and genetic mouse models of obesity [9], [10], [11], [12], [13], [14], [15]. Here, ITGAX is linked to obesity due to melanocortin 4 receptor deficiency.