Clearly, the metabolism of lipids differs between species, and thus we decided to target the APOBEC1 gene in another species than the mouse and closer to the human as regard to the metabolism of lipids, in order to investigate whether the APOBEC1 dependent editing could be a valuable target for fighting against obesity through modulating the lipid uptake. The gene discussed is APOBEC1; the disease is obesity due to melanocortin 4 receptor deficiency.