Considering the function of TG2 in cell adhesion, and its role in promoting the motility/survival signalling pathways on the cell surface 34,38, it is suggested that the inhibition of the invasion after knock-down of eEF-2K is mediated, in a part, through TG2 down-regulation, and the eEF-2K/TG2 axis promotes PaCa cells invasion. This evidence concerns the gene EEF2K and permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.