IPF cells exhibited decreased expression of CDKN2B and CARD10 and increased expression of MGMT compared to nonfibrotic control fibroblasts (Figure 3A–D), concordant with the observations that CDKN2B and CARD10 were hypermethylated and MGMT was hypomethylated in IPF cells. Here, CDKN2B is linked to idiopathic pulmonary fibrosis.