The carbohydrate-responsive element binding protein (ChREBP), another important regulator of the expression of lipogenic genes [32], was only expressed in detectable levels in the HepG2 cells (liver cancer cell line) (Supplementary Figure S4a) and in this cell line, we could not observe an activation and nuclear translocation of the transcription factor, when cultured in low-lipid conditions (Supplementary Figure S4b). The gene discussed is MLXIPL; the disease is liver cancer.