NPPB and congestive heart failure: Furthermore, the Spearman analysis showed that urinary ORM1 had a high positive correlation with the NYHA functional classification of CHF, indicating that the increased level of urinary ORM1 was associated with the CHF worsened, and the multivariate analysis indicated that the urinary ORM1 expression correlated with the plasma NT-proBNP (P = 0.002) and NYHA classification (P<0.001).