Furthermore, the multivariate analysis suggested that the urinary ORM1 content was associated with the NT-proBNP (OR: 2.106, 95% CI: 1.213–3.524, P = 0.002) and the NYHA classification of CHF (OR: 3.019, 95% CI: 1.329–4.721, P<0.001) (Table 5). This evidence concerns the gene NPPB and congestive heart failure.