In the past years, several genes linked to CHD have been identified, including T-box transcription factors (TBX1, TBX5 and TBX20), homobox transcription factors (NKX2.5 and NKX2.6), basic helix-loop-helix transcription factors (HAND1 and HAND2), and GATA binding protein 4 (GATA4) [9]. The gene discussed is GATA4; the disease is coronary artery disorder.