NFKB1 and rheumatoid arthritis: NF-κB activation by IL-1β induced the gene expressions of matrix metalloproteinases (MMPs) that are major products of cytokine stimulated fibroblast-like synovial cells (FLS) and efficiently degrade the collagenous components of cartilage and bone, leading to the joint deformity and pain in the patient with RA [58].