Diseases resulting from mutations in AICDA (ID: 57379), CD40 (ID: 958), UNG (ID: 7374), NEMO (ID: 8517), or NFKBIA (ID: 4792) genes are all involved in the CD154-CD40- NF-κB pathways and affected the class switch recombination (CSR), somatic hypermutation (SHM), or germinal center formation and form the subtypes of hyper-IgM syndromes. This evidence concerns the gene CD40 and hyper-IgM syndrome.