Recent studies have shown that TGF-β stimulation in rat renal mesangial cells can increase SET7/9 gene expression and SET7/9 recruitment to the promoters of key fibrotic genes (including PAI-1 and CTGF) linked to DN, which are associated with active H3K4me1 occupancy; high glucose stimulation can lead to similar change in RMCs; TGF-β specific antibody treatment can reverse HG induced gene expression and promoter histone methylation changes; these results highlight a key role of histone methylation and HMT SET7/9 in modulating renal gene expression leading to the pathogenesis of DN [43]. This evidence concerns the gene CCN2 and liver dysplastic nodule.