A recent study shows that both mice model and DN patients can develop polyuria due to the upregulation of Aqp5, in which Aqp5 acted as an Aqp2 binding partner and regulator and can impair Aqp2 membrane localization, and decreased H3K79me2 may contribute to the changes in DN patients and in mouse cortical collecting duct M1 cells models [45]. Here, AQP2 is linked to Polyuria.