One report showed that in uninephrectomized db/db mice kidney H3K4me2 level was increased in accordance with glomerular cell proliferation, albuminuria, and glomerular rate (GFR) reduction, and MCP-1/CCL2 antagonist treatment can prevent DN histopathological damage and H3K4me2 change in uninephrectomized db/db mice [56]. Here, CCL2 is linked to liver dysplastic nodule.