Results of a recent study from type 2 diabetes model db/db mice showed that, relative to db/+ mice, H3K4me1 level in glomeruli from db/db mice was increased in accordance with RNA polymerase II recruitment enhancement at the promoters of PAI-1 and RAGE (receptor for advanced glycation end products), whereas no differences were noted for H3K4me2/3. Here, SERPINE1 is linked to type 2 diabetes mellitus.