A study mentioned above shows that renal Aquaporin 2- (Aqp2-) expressing cells (DOT1LAC⁡) deficient mice can develop polyuria due to the upregulation of Aqp5, and decreased H3K79me2 caused by DOT1L deficiency may contribute to the changes in mouse cortical collecting duct M1 cells models [45]. This evidence concerns the gene AQP5 and Polyuria.