Another report showed that in OVE26 mice and STZ induced rat type 1 diabetes models renal gene expressions of Cox2 and MCP-1 only in mice were upregulated, associated with decreased H3K27me3 levels, which was accompanied by H3K27me3 demethylase KDM6A species-specific increases in mice but not in rats [47]. The gene discussed is CCL2; the disease is type 1 diabetes mellitus.