Acamprosate, which is a glutamate N-methyl-D-aspar-tate receptor antagonist, may reduce mGluR5 function, and is approved for alcohol dependence (Miller et al., 2011), has been found to decrease food craving and weight gain in individuals with alcoholism (McElroy et al., 2011, 2012). The gene discussed is GRM5; the disease is alcohol dependence.